Complement 3+-astrocytes are highly abundant in prion diseases, but their abolishment led to an accelerated disease course and early dysregulation of microglia

Table 1 Summary of clinical parameters of Creutzfeldt-Jakob patients enrolled with post mortem brain tissue samples in this study

Age	Sex	Diagnosis	Subtype	Disease duration [months]	14–3-3	RT-Quic
F	69	CJD	VV1	9	+	+
M	72	CJD	MM/MV1	n.a.	n.a.	n.a.
F	78	CJD	MM/MV1	n.a.	n.a.	n.a.
F	59	CJD	MV2K	45	n.a.	n.a.
M	78	CJD	MV2K + C	10	–	n.a.

ISSN: 2051-5960