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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Complement 3+-astrocytes are highly abundant in prion diseases, but their abolishment led to an accelerated disease course and early dysregulation of microglia

Fig. 3

Prion pathology in TKO- is similar to WT-mice at clinical time points a Determination of PrPC expression by Western blot and subsequent quantification of PrPC normalized to β-actin in age matched non-infected mice brain homogenates showed similar expression levels at the age of 200 days (corresponding to the clinical time point). b Representative H&E staining of hippocampus and thalamus of clinical prion diseased mice and age matched non-infected controls; scale bar: 50 μm. c Semi-quantitative determination of spongiosis levels showed no differences between clinical TKO versus WT mice (n = 4 individual mice each). In contrast, uninfected TKO or WT mice do not display spongiosis (n = 3 individual mice each)

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