Skip to main content
Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Complement 3+-astrocytes are highly abundant in prion diseases, but their abolishment led to an accelerated disease course and early dysregulation of microglia

Fig. 2

Triple-KO leads to significant acceleration of prion disease course a Western blot analysis of PrPSc after proteinase K digestion of brain tissue at 80 and 110 days p.i. and at clinical prion disease. Quantification of signal intensity showed that WT and Triple-KO mice do not show significant differences at all three investigated time points (n = 4 independent animals per group and time point) day80 p = 0.347; day 110 p = 0.126; clinical prion disease p = 0.297. b Kaplan-Meier survival curve of RML-prion infected WT- (n = 8 individual animals) and TKO-mice (n = 10 individual animals), Mantel-Cox log rank *** p = 0.0003. c Titers of prion infectivity as measured by bioassay in tga20-mice are similar in brains of WT- or TKO-mice 80 days post prion infection (p = 0.1451). Brain homogenates of two individual infected mice per group were injected into 4 individual tga20-mice, each

Back to article page