Table 3 Summary of αS pathology, microgliosis, and astrogliosis in each mouse line assessed for pathology induction with respective inoculums
Type of Inoculum | αS Pathology | Microgliosis | Astrogliosis | |
|---|---|---|---|---|
nTg | PBS | – | +/− | +/− |
nTg | Control Lysate | – | +/− | +/− |
nTg | MSA Lysate | – | +/− | +/− |
M20+/− | PBS | – | +/− | +/− |
M20+/− | Control Lysate | – | +/− | +/− |
M20+/− | MSA Lysate | – | +/− | +/− |
M83+/− | PBS | – | +/− | +/− |
M83+/− | Control Lysate | – | +/− | +/− |
M83+/− | MSA Lysate | +++ | ++ | +++ |
M83+/− | WT αS Fibrils | + | + | ++ |
M83+/− | A53T αS Fibrils | ++ | + | ++ |