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Table 3 Summary of αS pathology, microgliosis, and astrogliosis in each mouse line assessed for pathology induction with respective inoculums

From: Comparative analyses of the in vivo induction and transmission of α-synuclein pathology in transgenic mice by MSA brain lysate and recombinant α-synuclein fibrils

  Type of Inoculum αS Pathology Microgliosis Astrogliosis
nTg PBS +/− +/−
nTg Control Lysate +/− +/−
nTg MSA Lysate +/− +/−
M20+/− PBS +/− +/−
M20+/− Control Lysate +/− +/−
M20+/− MSA Lysate +/− +/−
M83+/− PBS +/− +/−
M83+/− Control Lysate +/− +/−
M83+/− MSA Lysate +++ ++ +++
M83+/− WT αS Fibrils + + ++
M83+/− A53T αS Fibrils ++ + ++
  1. For each mouse line, qualitative neuropathological grading of pathological inclusion burden and immunological response induced by each inoculum was graded on the following scale: (+/−) rare, (+) mild, (++) moderate, and (+++) severe. This grading for M83+/− injected with MSA lysates only include the mice that developed αS inclusion pathology