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Table 2 Summary of neonatal P0 mouse brain inoculation studies

From: Comparative analyses of the in vivo induction and transmission of α-synuclein pathology in transgenic mice by MSA brain lysate and recombinant α-synuclein fibrils

Type of Inoculums Mouse Line Injected
M83+/− M20+/− nTg
MSA Case 1 6/12 0/5 0/4
MSA Case 2 3/12 0/8 0/6
Control Case 1 0/8 0/4 0/4
Control Case 2 0/8 0/16 0/11
PBS 0/20 0/5 0/6
WT αS Fibrils 5/5   
A53T αS Fibrils 8/8   
  1. Number of mice with induced αS inclusion pathology per total number of mice injected for each cohort. Mouse lines: M83+/− and M20+/− transgenic mice and nTg mice. Inoculums: white matter cerebellum extracts from MSA or control individuals, PBS or in vitro aggregated recombinant WT or A53T human αS proteins