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Table 2 Summary of neonatal P0 mouse brain inoculation studies

From: Comparative analyses of the in vivo induction and transmission of α-synuclein pathology in transgenic mice by MSA brain lysate and recombinant α-synuclein fibrils

Type of Inoculums

Mouse Line Injected

M83+/−

M20+/−

nTg

MSA Case 1

6/12

0/5

0/4

MSA Case 2

3/12

0/8

0/6

Control Case 1

0/8

0/4

0/4

Control Case 2

0/8

0/16

0/11

PBS

0/20

0/5

0/6

WT αS Fibrils

5/5

  

A53T αS Fibrils

8/8

  
  1. Number of mice with induced αS inclusion pathology per total number of mice injected for each cohort. Mouse lines: M83+/− and M20+/− transgenic mice and nTg mice. Inoculums: white matter cerebellum extracts from MSA or control individuals, PBS or in vitro aggregated recombinant WT or A53T human αS proteins
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Acta Neuropathologica Communications

ISSN: 2051-5960

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