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Table 4 Differentially expressed genes in TNC cDNA vs. shRNA cell lines

From: Tenascin-C expression contributes to pediatric brainstem glioma tumor phenotype and represents a novel biomarker of disease

Gene Name logFC PValue adj.p
MIR30A −7.866092897 2.51674E-50 3.9996E-46
AC119673.1 −5.51977944 3.22561E-14 7.32306E-11
RPS3AP5 −3.022216042 4.38211E-10 4.0965E-07
AC007743.1 −2.374800701 1.81455E-08 1.35278E-05
AL163952.1 −2.225772302 9.52366E-06 0.001872888
CTD-2269F5.1 −2.180041946 0.000403098 0.025023561
RP11-777B9.5 −2.123763807 2.03315E-07 0.000100971
FSIP2 −2.121252851 1.13045E-06 0.000403974
RPL4P5 2.070466961 0.0002471 0.018610989
SAMD12 2.077983472 0.000150356 0.014061765
TNFSF15 2.09066531 0.000821066 0.038724462
SNORA84 2.212964724 4.60974E-07 0.000203494
RN7SL825P 2.21448533 2.17857E-05 0.003532848
AC092299.8 2.347033959 1.55329E-05 0.002773582
GCNT3 2.370843556 0.000972904 0.043553199
RP6-42F4.1 2.453535316 2.25622E-08 1.494E-05
RP11-553A10.1 2.484443136 0.001201734 0.048910983
RP11-290D2.6 2.494377813 1.86588E-05 0.003188456
SNORA76 2.503062118 3.45134E-05 0.005126049
SNORD3C 2.578909604 5.76928E-06 0.00130979
SNORA54 2.680209334 1.90238E-11 2.51939E-08
CA9 2.683101502 0.000191849 0.016161347
CTA-85E5.6 2.749870719 4.52651E-09 3.99641E-06
FRK 2.751839555 1.18463E-08 9.90845E-06
RP11-504P24.8 2.777831969 2.00742E-10 2.2787E-07
RP11-676 J15.1 2.80969822 0.000726166 0.035617995
SPINK1 2.838338406 0.000284132 0.020068546
WASH5P 2.896364617 2.37249E-27 1.88518E-23
RN7SKP185 2.897676479 9.16004E-13 1.81964E-09
RP11-230G5.2 2.921550791 5.15934E-05 0.00717505
CTD-2256P15.1 3.208660084 0.000516546 0.029320523
SNORA80B 3.276449172 1.68241E-12 2.97077E-09
SFTA1P 3.678556083 2.99678E-06 0.000780734
RP11-457 M11.2 3.793167305 2.15375E-11 2.63288E-08
TNC 5.130171422 3.0407E-21 1.20807E-17
RP11-182 L21.5 5.497636404 5.54817E-12 8.01559E-09
PTMAP5 5.663770365 4.27628E-15 1.13264E-11
LL22NC03-N14H11.1 7.391276313 7.34761E-27 3.89227E-23
  1. TNC expression was modified in pediatric supratentorial high-grade glioma (HGG n = 1) and brainstem glioma (DIPG n = 3) cell lines via lentiviral transfection of TNC shRNA and cDNA, with resulting gene expressions determined via RNA-Seq. Results were filtered for statistical significance (Log2Fold Change > 2 or < −2, adjusted p-value < 0.05), with 173 differentially expressed genes identified between TNC cDNA and shRNA cell lines. Of these, 38 genes, listed here, demonstrated the same expression pattern across all lines by experimental condition, including TNC and miRNA30, with differential expression values (cDNA vs shRNA, Log2Fold Change), pvalue and adjusted p-value indicated