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Table 4 Differentially expressed genes in TNC cDNA vs. shRNA cell lines

From: Tenascin-C expression contributes to pediatric brainstem glioma tumor phenotype and represents a novel biomarker of disease

Gene Name

logFC

PValue

adj.p

MIR30A

−7.866092897

2.51674E-50

3.9996E-46

AC119673.1

−5.51977944

3.22561E-14

7.32306E-11

RPS3AP5

−3.022216042

4.38211E-10

4.0965E-07

AC007743.1

−2.374800701

1.81455E-08

1.35278E-05

AL163952.1

−2.225772302

9.52366E-06

0.001872888

CTD-2269F5.1

−2.180041946

0.000403098

0.025023561

RP11-777B9.5

−2.123763807

2.03315E-07

0.000100971

FSIP2

−2.121252851

1.13045E-06

0.000403974

RPL4P5

2.070466961

0.0002471

0.018610989

SAMD12

2.077983472

0.000150356

0.014061765

TNFSF15

2.09066531

0.000821066

0.038724462

SNORA84

2.212964724

4.60974E-07

0.000203494

RN7SL825P

2.21448533

2.17857E-05

0.003532848

AC092299.8

2.347033959

1.55329E-05

0.002773582

GCNT3

2.370843556

0.000972904

0.043553199

RP6-42F4.1

2.453535316

2.25622E-08

1.494E-05

RP11-553A10.1

2.484443136

0.001201734

0.048910983

RP11-290D2.6

2.494377813

1.86588E-05

0.003188456

SNORA76

2.503062118

3.45134E-05

0.005126049

SNORD3C

2.578909604

5.76928E-06

0.00130979

SNORA54

2.680209334

1.90238E-11

2.51939E-08

CA9

2.683101502

0.000191849

0.016161347

CTA-85E5.6

2.749870719

4.52651E-09

3.99641E-06

FRK

2.751839555

1.18463E-08

9.90845E-06

RP11-504P24.8

2.777831969

2.00742E-10

2.2787E-07

RP11-676 J15.1

2.80969822

0.000726166

0.035617995

SPINK1

2.838338406

0.000284132

0.020068546

WASH5P

2.896364617

2.37249E-27

1.88518E-23

RN7SKP185

2.897676479

9.16004E-13

1.81964E-09

RP11-230G5.2

2.921550791

5.15934E-05

0.00717505

CTD-2256P15.1

3.208660084

0.000516546

0.029320523

SNORA80B

3.276449172

1.68241E-12

2.97077E-09

SFTA1P

3.678556083

2.99678E-06

0.000780734

RP11-457 M11.2

3.793167305

2.15375E-11

2.63288E-08

TNC

5.130171422

3.0407E-21

1.20807E-17

RP11-182 L21.5

5.497636404

5.54817E-12

8.01559E-09

PTMAP5

5.663770365

4.27628E-15

1.13264E-11

LL22NC03-N14H11.1

7.391276313

7.34761E-27

3.89227E-23

  1. TNC expression was modified in pediatric supratentorial high-grade glioma (HGG n = 1) and brainstem glioma (DIPG n = 3) cell lines via lentiviral transfection of TNC shRNA and cDNA, with resulting gene expressions determined via RNA-Seq. Results were filtered for statistical significance (Log2Fold Change > 2 or < −2, adjusted p-value < 0.05), with 173 differentially expressed genes identified between TNC cDNA and shRNA cell lines. Of these, 38 genes, listed here, demonstrated the same expression pattern across all lines by experimental condition, including TNC and miRNA30, with differential expression values (cDNA vs shRNA, Log2Fold Change), pvalue and adjusted p-value indicated
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Acta Neuropathologica Communications

ISSN: 2051-5960

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