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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Tenascin-C expression contributes to pediatric brainstem glioma tumor phenotype and represents a novel biomarker of disease

Fig. 3

Exogenous TNC increases pediatric glioma cell proliferation in vitro. Exogenous TNC was added to pediatric supratentorial high grade glioma (HGG n = 2) and brainstem glioma (DIPG n = 2) cell lines in vitro in technical triplicate. a Exposure of glioma cells in suspension to exogenous TNC at increasing concentration promotes cell proliferation in H3K27 M DIPG relative to H3K27WT HGG lines, with greatest effect at 1μg/mL dose (**p = 0.0079). X-axis: Concentration of exogenous TNC added to cell culture media (ug/mL). Y-axis: Rate of cell proliferation relative to control with no exogenous TNC (percent). b Exposure of adherent glioma cells in monolayer to exogenous TNC promotes cell proliferation relative to uncoated controls, with greatest effect in cell lines with low endogenous TNC expression. Y–axis: Rate of cell proliferation relative to no coat control (% normalized to control)

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Acta Neuropathologica Communications

ISSN: 2051-5960

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