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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Endogenous mouse huntingtin is highly abundant in cranial nerve nuclei, co-aggregates to Abeta plaques and is induced in reactive astrocytes in a transgenic mouse model of Alzheimer’s disease

Fig. 3

Immunohistochemical HTT labelling in coronal brain sections of Wistar rat. Note the high abundance of HTT immunoreactivity in medial septum (MS), caudate putamen (CPu), vertical and horizontal diagonal band (VDB/HDB), nucleus basalis magnocellularis (Nbm), oculomotor nerve nucleus (3), pedunculopontine tegmental nucleus (PPT), laterodorsal tegmental nucleus (LDT), nucleus abducens (6), nucleus facialis (7) and perifacial zone (P7). In addition and in contrast to mouse brain, significant HTT immunoreactivity was detected in cortical pyramidal neurons (Cx), and in cornu ammonis 1 (CA1) pyramidal and dentate gyrus (DG) granule neurons of the hippocampus

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