From: Cerebrospinal fluid from Alzheimer’s disease patients promotes tau aggregation in transgenic mice
patient number | group | diagnosis NIA-AA criteria | alternative clinical diagnosis | age | MMS | Brain MRI | SPECT | CSF tau (pg/ml) | CSF p-tau (pg/ml) | CSF Aβ (pg/ml) |
---|---|---|---|---|---|---|---|---|---|---|
1 | CTR | Dementia unlikely to be due to AD | vascular encephalopathy | 80 | 26 | vascular encephalopathy | no signs of AD or FTD, compatible with vascular encephalopathy | 500 | 78 | 544 |
2 | CTR | Dementia unlikely to be due to AD | neurocognitive deficits associated with progressive pancreas carcinoma and tumorectomy | 73 | 25 | mild vascular microangiopathy | – | 206 | 50 | 580 |
3 | CTR | MCI - unlikely to be due to AD | early Wernicke–Korsakoff syndrome | 61 | 30 | compatible with Wernicke-Korsakoff syndrome | compatible with Wernicke-Korsakoff syndrome | 162 | 43 | 928 |
4 | CTR | MCI - unlikely to be due to AD | depression | 57 | 28 | normal | – | 360 | 53 | 1133 |
1 | AD | Probable AD with high BP | – | 73 | 25 | hippocampal atrophy, no vascular lesions | – | 840 | 105 | 366 |
2 | AD | Probable AD with high BP | – | 61 | 24 | temporal brain atrophy | Left parietal decreased glucose metabolism compatible with early AD | 500 | 92 | 318 |
3 | AD | MCI - core clinical data | – | 79 | 28 | mild hippocampal atrophy | – | 759 | 119 | 516 |
4 | AD | Probable AD with intermediate BP | – | 71 | 23 | left hippocampal atrophy, microangiopathy | – | 308 | 77 | 240 |
5 | AD | Probable AD with intermediate BP | – | 74 | 21 | hippocampal and global brain atrophy, mild microangiopathy | – | 238 | 32 | 402 |