Skip to main content
Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Early neuronal accumulation of DNA double strand breaks in Alzheimer’s disease

Fig. 3

Pan-nuclear H2AX phosphorylation in neurons of humans and mice. a Representative confocal microscopic images of sections from the orbitofrontal cortex of an AD case from Cohort 1. Sections were immunostained for γH2AX (red) and NeuN (grey). Orange circles outline nuclei. Two distinct patterns of γH2AX immunoreactivity were observed: foci (white arrows) and pan-nuclear (green arrows). Scale bar: 10 μm. b Representative confocal images of sections from the CA1 region of a mouse. Sections were immunostained for γH2AX (red) and parvalbumin (grey). Green arrows highlight the large proportion of parvalbumin-positive interneurons showing pan-nuclear γH2AX labeling under physiological conditions. Scale bar: 50 μm

Back to article page