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Table 2 PIK3CA mutation was significantly associated with shorter survival after adjusting for age, KPS, gross total resection, IDH1 mutation, and MGMT promoter methylation

From: PIK3CA activating mutations are associated with more disseminated disease at presentation and earlier recurrence in glioblastoma

  Univariate analysis Multivariate analysis
  P value P value HR
[PFS]
 High age 0.0004* 0.005* 1.03 (1.01–1.05)#
 High KPS score 0.10 0.28 0.99 (0.97–1.01)#
 Gross total resection 0.02* 0.17 0.75 (0.49–1.13)
PIK3CA mutation 0.03* 0.01* 2.89 (1.30–5.90)
IDH1 mutation < 0.0001* 0.002* 0.10 (0.006–0.50)
MGMT promoter methylation < 0.0001* < 0.0001* 0.33 (0.21–0.52)
[OS]
 High age 0.0004* 0.003* 1.03 (1.01–1.05)#
 High KPS score 0.047* 0.32 0.99 (0.96–1.01)#
 Gross total resection 0.11 0.53 0.87 (0.55–1.35)
PIK3CA mutation 0.19 0.049* 2.32 (1.00–4.88)
IDH1 mutation < 0.0001* 0.02* 0.15 (0.008–0.74)
MGMT promoter methylation < 0.0001* < 0.0001* 0.27 (0.17–0.44)
  1. * Statistical significance: P ≤ 0.05
  2. # HR per unit
  3. Abbreviations: PFS, progression-free survival; OS, overall survival; KPS, Karnofsky performance status; IDH1, isocitrate dehydrogenase 1; MGMT, O6-methylguanine-DNA methyltransferase; HR, hazard ratio