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Table 2 PIK3CA mutation was significantly associated with shorter survival after adjusting for age, KPS, gross total resection, IDH1 mutation, and MGMT promoter methylation

From: PIK3CA activating mutations are associated with more disseminated disease at presentation and earlier recurrence in glioblastoma

 

Univariate analysis

Multivariate analysis

 

P value

P value

HR

[PFS]

 High age

0.0004*

0.005*

1.03 (1.01–1.05)#

 High KPS score

0.10

0.28

0.99 (0.97–1.01)#

 Gross total resection

0.02*

0.17

0.75 (0.49–1.13)

 PIK3CA mutation

0.03*

0.01*

2.89 (1.30–5.90)

 IDH1 mutation

< 0.0001*

0.002*

0.10 (0.006–0.50)

 MGMT promoter methylation

< 0.0001*

< 0.0001*

0.33 (0.21–0.52)

[OS]

 High age

0.0004*

0.003*

1.03 (1.01–1.05)#

 High KPS score

0.047*

0.32

0.99 (0.96–1.01)#

 Gross total resection

0.11

0.53

0.87 (0.55–1.35)

 PIK3CA mutation

0.19

0.049*

2.32 (1.00–4.88)

 IDH1 mutation

< 0.0001*

0.02*

0.15 (0.008–0.74)

 MGMT promoter methylation

< 0.0001*

< 0.0001*

0.27 (0.17–0.44)

  1. * Statistical significance: P ≤ 0.05
  2. # HR per unit
  3. Abbreviations: PFS, progression-free survival; OS, overall survival; KPS, Karnofsky performance status; IDH1, isocitrate dehydrogenase 1; MGMT, O6-methylguanine-DNA methyltransferase; HR, hazard ratio