Fig. 2

Representative cases of PIK3CA mutant glioblastomas demonstrating widespread disease at presentation. a The tumors were multicentric, affecting the left frontal and left parietal lobes without any intervening T2/fluid attenuated inversion recovery abnormality. b The tumor diffusely involved multiple lobes including the right frontal, parietal, and occipital lobes as well as the left parietal lobe. c The main tumor was located in the left posterior mesial temporal lobe with leptomeningeal involvement of the adjacent brain such as the midbrain and pons. Distant lesions were also observed on the ventral surface of the pons and the dorsal surface of the cervical spinal cord