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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Divergence in the activity of the N- and C- catalytic domains of ACE1 - implications for the role of the renin-angiotensin system in Alzheimer’s disease

Fig. 1

Divergent activity of ACE1 domains in Alzheimer’s disease. Bar charts showing (a) significantly higher ACE1 C-domain (Ang-II production) activity in AD compared to age-matched controls and (b) significantly reduced ACE1 N-domain activity (Aβ degradation) compared to age-matched controls in the mid-frontal cortex in AD (n = 72) and age-matched (n = 48). Bars show the median and 95% CI, Mann-Whitney test was used to compare ACE1 C-domain activity between groups. p < 0.05 was considered statistically significant

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