TY - JOUR AU - Burger, D. AU - Reudelhuber, T. L. AU - Mahajan, A. AU - Chibale, K. AU - Sturrock, E. D. AU - Touyz, R. M. PY - 2014 DA - 2014// TI - Effects of a domain-selective ACE inhibitor in a mouse model of chronic angiotensin II-dependent hypertension JO - Clin Sci (Lond) VL - 127 UR - https://doi.org/10.1042/CS20130808 DO - 10.1042/CS20130808 ID - Burger2014 ER - TY - JOUR AU - Davies, N. M. AU - Kehoe, P. G. AU - Ben-Shlomo, Y. AU - Martin, R. M. PY - 2011 DA - 2011// TI - Associations of anti-hypertensive treatments with Alzheimer's disease, vascular dementia, and other dementias JO - J Alzheimers Dis VL - 26 UR - https://doi.org/10.3233/JAD-2011-110347 DO - 10.3233/JAD-2011-110347 ID - Davies2011 ER - TY - JOUR AU - Eckman, E. A. AU - Adams, S. K. AU - Troendle, F. J. AU - Stodola, B. A. AU - Kahn, M. A. AU - Fauq, A. H. PY - 2006 DA - 2006// TI - Regulation of steady-state beta-amyloid levels in the brain by neprilysin and endothelin-converting enzyme but not angiotensin-converting enzyme JO - J Biol Chem VL - 281 UR - https://doi.org/10.1074/jbc.M605827200 DO - 10.1074/jbc.M605827200 ID - Eckman2006 ER - TY - JOUR AU - Elkins, J. S. AU - Douglas, D. V. AU - Johnston, S. C. PY - 2004 DA - 2004// TI - Alzheimer disease risk and genetic variation in ACE: a meta analysis JO - Neurology. VL - 62 UR - https://doi.org/10.1212/01.WNL.0000106823.72493.FF DO - 10.1212/01.WNL.0000106823.72493.FF ID - Elkins2004 ER - TY - JOUR AU - Hajjar, I. AU - Hart, M. AU - Chen, Y. L. AU - Mack, W. AU - Milberg, W. AU - Chui, H. PY - 2012 DA - 2012// TI - Effect of antihypertensive therapy on cognitive function in early executive cognitive impairment: a double-blind randomized clinical trial JO - Arch Intern Med VL - 172 UR - https://doi.org/10.1001/archinternmed.2011.1391 DO - 10.1001/archinternmed.2011.1391 ID - Hajjar2012 ER - TY - JOUR AU - Hajjar, I. AU - Levey, A. PY - 2015 DA - 2015// TI - Association between angiotensin receptor blockers and longitudinal decline in tau in mild cognitive impairment JO - JAMA Neurol VL - 72 UR - https://doi.org/10.1001/jamaneurol.2015.1001 DO - 10.1001/jamaneurol.2015.1001 ID - Hajjar2015 ER - TY - JOUR AU - Hemming, M. L. AU - Selkoe, D. J. PY - 2005 DA - 2005// TI - Amyloid beta-protein is degraded by cellular angiotensin-converting enzyme (ACE) and elevated by an ACE inhibitor JO - J Biol Chem VL - 280 UR - https://doi.org/10.1074/jbc.M508460200 DO - 10.1074/jbc.M508460200 ID - Hemming2005 ER - TY - JOUR AU - Hu, J. AU - Igarashi, A. AU - Kamata, M. AU - Nakagawa, H. PY - 2001 DA - 2001// TI - Angiotensin-converting enzyme degrades Alzheimer amyloid beta-peptide (a beta ); retards a beta aggregation, deposition, fibril formation; and inhibits cytotoxicity JO - J Biol Chem VL - 276 UR - https://doi.org/10.1074/jbc.M104068200 DO - 10.1074/jbc.M104068200 ID - Hu2001 ER - TY - JOUR AU - Kehoe, P. G. PY - 2018 DA - 2018// TI - The coming of age of the angiotensin hypothesis in Alzheimer's disease: Progress toward disease prevention and treatment? JO - J Alzheimers Dis VL - 62 UR - https://doi.org/10.3233/JAD-171119 DO - 10.3233/JAD-171119 ID - Kehoe2018 ER - TY - JOUR AU - Kehoe, P. G. AU - Davies, N. M. AU - Martin, R. M. AU - Ben-Shlomo, Y. PY - 2013 DA - 2013// TI - Associations of angiotensin targeting antihypertensive drugs with mortality and hospitalization in primary care patients with dementia JO - J Alzheimers Dis VL - 33 UR - https://doi.org/10.3233/JAD-2012-121090 DO - 10.3233/JAD-2012-121090 ID - Kehoe2013 ER - TY - JOUR AU - Kehoe, P. G. AU - Hibbs, E. AU - Palmer, L. E. AU - Miners, J. S. PY - 2017 DA - 2017// TI - Angiotensin-III is increased in Alzheimer's disease in association with amyloid-beta and tau pathology JO - J Alzheimers Dis VL - 58 UR - https://doi.org/10.3233/JAD-161265 DO - 10.3233/JAD-161265 ID - Kehoe2017 ER - TY - JOUR AU - Kehoe, P. G. R. C. AU - McIlory, S. AU - Williams, H. AU - Holmans, P. AU - Holmes, C. AU - Liolitsa, D. AU - Vahidassr, D. AU - Powell, J. AU - McGleenon, B. AU - Liddell, M. AU - Plomin, R. AU - Dynan, K. AU - Williams, N. AU - Neal, J. AU - Cairns, N. J. AU - Wilcock, G. AU - Passmore, P. AU - Lovestone, S. AU - Williams, J. AU - Owen, M. J. PY - 1999 DA - 1999// TI - Variation in DCP1, encoding ACE, is associated with susceptibility to Alzheimer disease JO - Nat Genet VL - 21 UR - https://doi.org/10.1038/5009 DO - 10.1038/5009 ID - Kehoe1999 ER - TY - JOUR AU - Kugaevskaya, E. V. AU - Veselovsky, A. V. AU - Indeykina, M. I. AU - Solovyeva, N. I. AU - Zharkova, M. S. AU - Popov, I. A. PY - 2018 DA - 2018// TI - N-domain of angiotensin-converting enzyme hydrolyzes human and rat amyloid-beta (1-16) peptides as arginine specific endopeptidase potentially enhancing risk of Alzheimer's disease JO - Sci Rep VL - 8 UR - https://doi.org/10.1038/s41598-017-18567-5 DO - 10.1038/s41598-017-18567-5 ID - Kugaevskaya2018 ER - TY - JOUR AU - Lehmann, D. J. AU - Cortina-Borja, M. AU - Warden, D. R. AU - Smith, A. D. AU - Sleegers, K. AU - Prince, J. A. PY - 2005 DA - 2005// TI - Large meta-analysis establishes the ACE insertion-deletion polymorphism as a marker of Alzheimer's disease JO - Am J Epidemiol VL - 162 UR - https://doi.org/10.1093/aje/kwi202 DO - 10.1093/aje/kwi202 ID - Lehmann2005 ER - TY - JOUR AU - Li, N. C. AU - Lee, A. AU - Whitmer, R. A. AU - Kivipelto, M. AU - Lawler, E. AU - Kazis, L. E. PY - 2010 DA - 2010// TI - Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: prospective cohort analysis JO - BMJ. VL - 340 UR - https://doi.org/10.1136/bmj.b5465 DO - 10.1136/bmj.b5465 ID - Li2010 ER - TY - JOUR AU - Miners, J. S. AU - Ashby, E. AU - Helmond, Z. AU - Chalmers, K. A. AU - Palmer, L. E. AU - Love, S. PY - 2008 DA - 2008// TI - Angiotensin-converting enzyme (ACE) levels and activity in Alzheimer's disease, and relationship of perivascular ACE1 to cerebral amyloid angiopathy JO - Neuropathol Appl Neurobiol VL - 34 UR - https://doi.org/10.1111/j.1365-2990.2007.00885.x DO - 10.1111/j.1365-2990.2007.00885.x ID - Miners2008 ER - TY - JOUR AU - Montine, T. J. AU - Phelps, C. H. AU - Beach, T. G. AU - Bigio, E. H. AU - Cairns, N. J. AU - Dickson, D. W. PY - 2012 DA - 2012// TI - National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach JO - Acta Neuropathol VL - 123 UR - https://doi.org/10.1007/s00401-011-0910-3 DO - 10.1007/s00401-011-0910-3 ID - Montine2012 ER - TY - JOUR AU - Oba, R. AU - Igarashi, A. AU - Kamata, M. AU - Nagata, K. AU - Takano, S. AU - Nakagawa, H. PY - 2005 DA - 2005// TI - The N-terminal active Centre of human angiotensin-converting enzyme degrades Alzheimer amyloid beta-peptide JO - Eur J Neurosci VL - 21 UR - https://doi.org/10.1111/j.1460-9568.2005.03912.x DO - 10.1111/j.1460-9568.2005.03912.x ID - Oba2005 ER - TY - JOUR AU - Toropygin, I. Y. AU - Kugaevskaya, E. V. AU - Mirgorodskaya, O. A. AU - Elisseeva, Y. E. AU - Kozmin, Y. P. AU - Popov, I. A. PY - 2008 DA - 2008// TI - The N-domain of angiotensin-converting enzyme specifically hydrolyzes the Arg-5-His-6 bond of Alzheimer's Abeta-(1-16) peptide and its isoAsp-7 analogue with different efficiency as evidenced by quantitative matrix-assisted laser desorption/ionization time-of-flight mass spectrometry JO - Rapid Commun Mass Spectrom VL - 22 UR - https://doi.org/10.1002/rcm.3357 DO - 10.1002/rcm.3357 ID - Toropygin2008 ER - TY - JOUR AU - Zou, K. AU - Maeda, T. AU - Watanabe, A. AU - Liu, J. AU - Liu, S. AU - Oba, R. PY - 2009 DA - 2009// TI - Abeta42-to-Abeta40- and angiotensin-converting activities in different domains of angiotensin-converting enzyme JO - J Biol Chem VL - 284 UR - https://doi.org/10.1074/jbc.M109.011437 DO - 10.1074/jbc.M109.011437 ID - Zou2009 ER - TY - JOUR AU - Zou, K. AU - Yamaguchi, H. AU - Akatsu, H. AU - Sakamoto, T. AU - Ko, M. AU - Mizoguchi, K. PY - 2007 DA - 2007// TI - Angiotensin-converting enzyme converts amyloid beta-protein 1-42 (Abeta (1-42)) to Abeta (1-40), and its inhibition enhances brain Abeta deposition JO - J Neurosci VL - 27 UR - https://doi.org/10.1523/JNEUROSCI.1549-07.2007 DO - 10.1523/JNEUROSCI.1549-07.2007 ID - Zou2007 ER -