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Table 1 Median-effect doses (%viability) of Delta-24-RGD alone or combined with different doses of radiotherapy in the pHGG and DIPG cell lines. The value is the viability percentage ± SD of cells irradiated with different doses or cells irradiated with different doses and infected with a single viral dose. The interaction between RT and Delta-24-RGD in pHGG and DIPG cell lines was measured by combination index (CI) values. The interaction was measured according to the combination index values. Combination index values > 1.3 indicated antagonism, values between 1.1 and 1.3 indicated moderate antagonism, values between 0.9 and 1.1 indicated additivity, values between 0.8 and 0.9 indicated slight synergy, values between 0.6 and 0.8 indicated moderate synergy, values between 0.4 and 0.6 indicated synergy, and values < 0.4 indicated strong synergy. Each combination was studied in three independent experiments, the differences of which were not statistically significant. The results of single experiments are shown

From: Delta-24-RGD combined with radiotherapy exerts a potent antitumor effect in diffuse intrinsic pontine glioma and pediatric high grade glioma models

  Cell lines IR (Gy) Mock +Delta-24-RGD CI
pHGG CHLA-03-AA 3 94.76 ± 7.07 54.77 ± 7.07 1.10
6 86.26 ± 5.2 47.17 ± 7.74 0.76
12 53.10 ± 5.23 35.33 ± 5.03 0.41
PBT-24 3 90.1 ± 3.03 38.2 ± 3.13 0.45
6 81.4 ± 6.74 29.9 ± 7.22 0.36
12 73.9 ± 4.46 19.9 ± 8.66 0.19
DIPG TP54 3 93.5 ± 9.19 16.0 ± 7.07 0.33
6 58.5 ± 7.7 10.2 ± 0.35 0.18
12 22.5 ± 0.7 6.5 ± 0.7 0.17
SU-DIPG IV 3 88.0 ± 1 38.2 ± 3.13 0.97
6 82.0 ± 6.74 29.9 ± 7.22 0.48
12 73.9 ± 4.46 19.9 ± 8.66 0.19
  1. IR Irradiated dosage, CI Combinatory index, Mock non infected cells