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Table 2 Unbiased stereological quantification of Iba-1. Mean ± SEM represent Iba-1-positive cells/mm3 in the OB layers, AON and Pir. Statistical analysis was focused on comparisons: genotype in the right hemisphere, left hemisphere, interhemispheric differences in WT and TG. For statistical data, see Additional file 4: Tables S10-S13. For abbreviations, see list

From: Neurodegeneration and contralateral α-synuclein induction after intracerebral α-synuclein injections in the anterior olfactory nucleus of a Parkinson’s disease A53T mouse model

Iba-1 positive cells (cells/mm3)

Brain region

Genotype

Post-injection time

Right hemisphere

Left hemisphere

Treatment

Treatment

Saline-injection

α-synuclein-injection

Saline-injection

α-synuclein-injection

GL

WT

2 m

8600 ± 475

9726 ± 1253

10,463 ± 931

8519 ± 1543

4 m

1359 ± 199.1

3028 ± 618.1

856 ± 348.1

2617 ± 613.9

TG

2 m

7583 ± 778.3

9249 ± 2388

7860 ± 548

10,569 ± 1451

EPL

WT

2 m

8260 ± 1297

9412 ± 538.3

8828 ± 594.3

7514 ± 1019

4 m

833.4 ± 124.5

1086 ± 234.2

639.5 ± 303.8

1613 ± 582.3

TG

2 m

7421 ± 782

8102 ± 482

7543 ± 531

6762 ± 544

MiL

WT

2 m

8939 ± 2174

10,807 ± 1040

8921 ± 1831

9984 ± 1285

4 m

935.6 ± 449.1

1162 ± 289.6

314.3 ± 98.62

1599 ± 642.4

TG

2 m

9080 ± 521

4513 ± 1421

10,296 ± 549

6338 ± 1048

IPL

WT

2 m

12,870 ± 3512

11,089 ± 1404

13,703 ± 279.3

10,294 ± 1572

4 m

1134 ± 402.8

1066 ± 306.5

948.7 ± 481.7

2209 ± 1070

TG

2 m

14,126 ± 1671

8969 ± 4074

12,480 ± 2987

9101 ± 3479

GrL

WT

2 m

9897 ± 361.6

10,597 ± 733.6

10,044 ± 321.80

8839 ± 1185

4 m

827.8 ± 230.5

1301 ± 364.3

265.6 ± 62.71

1659 ± 662.9

TG

2 m

8646 ± 876

11,231 ± 1751

9316 ± 934

10,632 ± 567

AON

WT

2 m

10,536 ± 1506

10,687 ± 2337

10,031 ± 1196

8168 ± 1690

4 m

700.3 ± 425.8

555.7 ± 385.8

0 ± 0

321.1 ± 230.7

TG

2 m

8665 ± 1015

8084 ± 2493

8810 ± 703

9251 ± 1681

Pir

WT

2 m

8202 ± 1371

8798 ± 1763

8395 ± 471.5

8241 ± 2339

4 m

108 ± 74.58

330.7 ± 143.7

0 ± 0

684.8 ± 569.9

TG

2 m

7151 ± 882

9312 ± 1061

9025 ± 546

6999 ± 507