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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Neurodegeneration and contralateral α-synuclein induction after intracerebral α-synuclein injections in the anterior olfactory nucleus of a Parkinson’s disease A53T mouse model

Fig. 3

Immunohistochemistry of α-synuclein aggregates in coronal sections of OB (a-h) and AON (i, j). Images b, d, f, h and j are high-magnification of images a, c, e, g and i, respectively. Colors squares indicate how stereological quantification of aggregates has been performed using optical dissector as shown in Fig. 4. Focusing on saline-injected TG, α-synuclein aggregates were decreased in RH (a, b) as compared to LH (c, d). In comparison, α-synuclein injection gave rise higher number of aggregates in RH (e, f) and particularly in LH (g, h). In WT, α-synuclein injection was only observed in AON (i, j). Scale bar a, c, e, g: 250 μm; b, d, f, h-j: 50 μm. For abbreviations, see list

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