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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis

Fig. 1

Prediction of candidate compounds from inverse gene profiling. a Detailed mapping of organ involvement by ex vivo BLI of a representative NOD.CB17-Prkdcscid/NcrCrl mouse seven weeks after intracardial injection of 5 × 105 H1_DL2 cells (n = 7). b Dendrogram of all replicates (n = 3 per organ) based upon cluster analysis of gene expression profiles. Numbers 1, 2 and 3 indicate sample ID. c Top ten compounds from the Connectivity Map (cMap) analysis with the potential to induce the opposite transcriptional response to the brain metastasis signature («anti-brain metastasis signature»). Chemical abstracts service (CAS) registry numbers, reported dose tested, cMap score and molecular weight (MW) are provided. A cMap score of − 1 indicates complete reversal of the signature (negative correlation)

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