Fig. 8

Lesion specific signatures and their biggest de novo network enrichment. a The heatmap indicates all differentially expressed genes (DEGs, FDR < 0.05) uniquely expressed in each lesion type (vertical lines). b By using KeyPathwayMiner, we retrieved the biggest de novo network from each of the lesion-specific gene list indicated on Fig. 8a: 56 nodes (log₂FC > 1) (k = 0) in active; 59 nodes (log₂FC > 1) (k = 0) in remyelinating; 31 nodes (k = 2, TB53, UBC) in chronic active; and 26 nodes (log₂FC > 1), (k = 2, HEL2, UBC) in inactive lesions. k = exception nodes, genes not differentially expressed; UBC = ubiquitin C; TB53 = Tumor Suppressor P53; HEL2 = E3 ubiquitin-protein ligase/14–3-3 epsilon. More intensive colour indicates higher betweenness centrality of hubs. FC = fold change; FDR = false discovery rate