Fig. 7

Immunoglobulin signatures and B cells in WM lesions of patients with progressive MS. a Immunoglobulin transcripts among the top 10 upregulated DEGs (FDR < 0.05) in the global MS white matter (WM) tissue compared to control WM tissue. b Distribution of CD20⁺ cells within the different MS lesions used also for generating transcriptome signatures. c Number of CD20⁺ cells in active (n = 3) and remyelinating (n = 4) lesions, each lesion from different brains. The same brains and lesions were used for generating transcriptome signatures. Around 10 pictures per lesion in each patient were taken at magnification of 20x and the average cell number per lesion were calculated. Statistical difference between the CD20⁺ cells was calculated using the Mann-Whitney test. d Heatmap of immunoglobulin transcripts in the different lesion types. FDR: false discovery rate