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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: RETRACTED ARTICLE: Unique RNA signature of different lesion types in the brain white matter in progressive multiple sclerosis

Fig. 6

TGFβ-R2 in remyelinating versus chronic active lesions. a De-novo enriched protein-protein network of significant differentially regulated genes (DEGs, FDR < 0.05) that were downregulated in chronic active and upregulated in remyelinating lesions (63 nodes, 117 protein connections). b Genes of TGFβ receptors and ligands in different lesion types. Asterisk indicates significant changes (FDR < 0.05). c TGFβ-R2 protein expression in remyelinating lesions. d TGFBR2 (green) RNA co-localizes with GFAP (red) RNA in remyelinating lesions by RNAscope. e TGFBR2 (green) RNA do not co-localize with IBA1 RNA by RNAscope. FDR: false discovery rate

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