Skip to main content
Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: RETRACTED ARTICLE: Unique RNA signature of different lesion types in the brain white matter in progressive multiple sclerosis

Fig. 5

Chitinase-3-like protein 1 (CHI3L1) in the rim of chronic active lesions. a RNA expression of CHI3L1 gene in each lesion type. log2FC (fold change) and significance (FDR, false discovery rate) is shown. b Protein expression of CHI3L1 protein in each lesion type. c Protein expression of CHI3L1 in the rim of chronic active lesion, and MOG staining defining the edge of the same lesion. d Protein expression of GFAP (brown) and RNA expression of CHI3L1 (red) in same cells (combined immunohistochemistry and RNAscope). e Co-localized RNA expression of GFAP (red) with CHI3L1 (green) by RNAscope. f Protein expression of MHCII (brown) and RNA expression of CHI3L1 (red) in different cells close to each other at the rim of the lesion (combined immunohistochemistry and RNAscope). g RNA expression of IBA1 (red) and CHI3L1 (green) (RNAscope). WM: white matter, NAWM: normal appearing white matter. FDR: false discovery rate

Back to article page
\