How to demix Alzheimer-type and PSP-type tau lesions out of their mixture -hybrid approach to dissect comorbidity-

Table 1 Demographic data on 5 patients with neuropathological diagnosis of AD and PSP.

Case	Age at death	Sex	Clinical diagnosis	Dementia	Parkinsonism	Duration of illness (year)	Neuropathological findings	Brain weight (g)	Braak NFT stage	Braak Amyloid stage
1	86	F	CHF	–	–	N. A	PSP, AD	1205	II	0
2	94	M	possible DLB	+	+	3	LB pathology, PSP, AD, AGD	1260	III	A
3	81	M	AD	+	–	9	PSP, AD	1230	V	C
4	85	M	pneumonia	N. A	N. A	N. A	PSP, AD, CAA	1395	V	C
5	80	M	possible PSP	+	+	8	PSP, AD, AGD	1210	VI	C

AD Alzheimer disease, AG argyrophilic grain disease, CAA cerebral amyloid angiopathy, CHF congestive heart failure, DLB dementia with Lewy body, N. A not available, NFT neurofibrillary tangle, PSP progressive supranuclear palsy

ISSN: 2051-5960