Table 3 AD neuropahological changes in sCJD and gCJD
sCJD | gCJDa | p | sCJDMM(V)1 | V210I | p | E200Kb | pc | |
|---|---|---|---|---|---|---|---|---|
ABC score | ||||||||
Not | 144 (37.3) | 29 (45.3) | 0.481 | 93 (34.4) | 9 (30.0) | 0.747 | 11 (55.0) | 0.170 |
Low | 210 (54.4) | 30 (46.9) | 152 (56.3) | 17 (56.7) | 8 (40.0) | |||
Intermediate/High | 32 (8.3) | 5 (7.8) | 25 (9.3) | 4 (13.3) | 1 (5.0) | |||
Thal score | ||||||||
0 | 144 (37.3) | 29 (45.3) | 0.577 | 93 (34.4) | 9 (30.0) | 0.835 | 11 (55.0) | 0.256 |
1–2 | 118 (30.6) | 15 (23.4) | 84 (31.1) | 8 (26.7) | 4 (20.0) | |||
3 | 76 (19.7) | 13 (20.3) | 56 (20.7) | 8 (26.7) | 4 (20.0) | |||
4–5 | 48 (12.4) | 7 (10.9) | 37 (13.7) | 5 (16.7) | 1 (5.0) | |||
CAA | ||||||||
Not CAA | 275 (71.2) | 47 (73.4) | 0.422 | 187 (69.3) | 22 (73.3) | 0.409 | 15 (75.0) | 0.398 |
CAA | 111 (28.8) | 17 (26.6) | 83 (30.7) | 8 (26.7) | 5 (25.0) | |||
Braak score | ||||||||
0 − + | 208 (53.9) | 34 (53.1) | 0.562 | 133 (49.3) | 11 (36.7) | 0.377 | 13 (65.0) | 0.328 |
I-II | 133 (34.5) | 25 (39.1) | 102 (37.8) | 15 (50.0) | 6 (30.0) | |||
> III | 45 (11.7) | 5 (7.8) | 35 (13.0) | 4 (13.3) | 1 (5.0) | |||
n | 386 | 64 | – | 270 | 30 | – | 20 | – |
Age at death (years) | 68.6 ± 8.9 | 65.0 ± 9.4 | – | 69.6 ± 8.3 | 65.9 ± 8.6 | – | 63.0 ± 9.1 | – |