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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: DNA methylation, transcriptome and genetic copy number signatures of diffuse cerebral WHO grade II/III gliomas resolve cancer heterogeneity and development

Fig. 4

Cell type, micro-environmental immune cell and treatment-resistance characteristics. a Heatmaps of expression and methylation levels of single-cell signatures taken from [59] reveal subtype-specific activation of astrocyte-, oligodendrocyte- and stem cell-like characteristics. b Digital immune cell-type decomposition of glioma transcriptomes using CIBERSORT [46] (see Fig. S21 for the full set of cells considered) on sample (above) and mean subtype levels for selected leukocyte cells across the expression subtypes. c The boxplots of expression and methylation levels of a transcriptomic drug and radiation resistance signature containing 50 genes [54] suggest largest resistance effects in E3 and E1. Expression and methylation levels of the subgroups anti-correlate (right part)

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