Microglia are not required for prion-induced retinal photoreceptor degeneration

Table 2 The effect of PLX5622 drug treatment on PrPSc deposition in 79A scrapie-infected retinal inner segment, as detected by anti-PrP (D13) antibody staining

dpi Days post inoculation, na Not available
^aEach number represents mean PrPSc score of two sections from one mouse. Entire retinal sections were scored for PrPSc present in the IS, as follows; 0 = No staining visible in the inner segment over entire retinal section; 1 = Low: less than 50 scattered deposits; 2 = Medium: more than 50 deposits; 3 = High: staining confluent along entire section; D, degenerated inner and outer segment, so assessment of staining not possible
^bPLX5622 drug treatment was initiated at 90dpi, thus mice were not available at 67, 82 dpi. Last PLX5622-treated animal was euthanized at 134dpi

ISSN: 2051-5960