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Table 1 The effect of PLX5622 treatment on the types of cells infiltrating the retinal inner and outer segments during scrapie disease

From: Microglia are not required for prion-induced retinal photoreceptor degeneration

 

Time (dpi)

82

104

118

129/131

134

144

153

159/163

No Drug

n

2

2

2

2

0

2

2a

2a

IBA1

1,1b

5,14

15,14

26,22

na

23,27

26,12

6,10

GFP

1,0

4,15

9,18

18,22

na

25,30

19,10

6,8

RFP

0,0

0

0,2

1,0

na

1,3

3,2

1,1

PLX5622c

n

0

2

2

5

1a

0

0

0

IBA1

na

0,0

0,2

1,2,2,4,4

7

   

GFP

na

1,0

1,2

0,2,2,4,2

8

   

RFP

na

0

0

1,1,0,1,0

3

   
  1. dpi Days post inoculation, n Number of animals tested, IBA1 Ionized calcium binding adaptor molecule 1 (microglia, monocyte-macrophage marker), GFP Green fluorescent protein (microglial marker), RFP Red fluorescent protein (monocyte-macrophage marker), na not available
  2. aeuthanized for severe clinical disease
  3. beach number represents the mean number of IHC marker-positive, nucleated cells counted in the inner or outer segment areas per two retinal sections from one mouse. Fractional numbers were rounded up to next whole integer
  4. cPLX5622 treatment was initiated at 90dpi and the last PLX5622-treated animal was euthanized at 134dpi