| Time (dpi) |
---|
82 | 104 | 118 | 129/131 | 134 | 144 | 153 | 159/163 |
---|
No Drug |
n
| 2 | 2 | 2 | 2 | 0 | 2 | 2a | 2a |
IBA1
| 1,1b | 5,14 | 15,14 | 26,22 |
na
| 23,27 | 26,12 | 6,10 |
GFP
| 1,0 | 4,15 | 9,18 | 18,22 |
na
| 25,30 | 19,10 | 6,8 |
RFP
| 0,0 | 0 | 0,2 | 1,0 |
na
| 1,3 | 3,2 | 1,1 |
PLX5622c |
n
| 0 | 2 | 2 | 5 | 1a | 0 | 0 | 0 |
IBA1
|
na
| 0,0 | 0,2 | 1,2,2,4,4 | 7 | Â | Â | Â |
GFP
|
na
| 1,0 | 1,2 | 0,2,2,4,2 | 8 | Â | Â | Â |
RFP
|
na
| 0 | 0 | 1,1,0,1,0 | 3 | Â | Â | Â |
- dpi Days post inoculation, n Number of animals tested, IBA1 Ionized calcium binding adaptor molecule 1 (microglia, monocyte-macrophage marker), GFP Green fluorescent protein (microglial marker), RFP Red fluorescent protein (monocyte-macrophage marker), na not available
- aeuthanized for severe clinical disease
- beach number represents the mean number of IHC marker-positive, nucleated cells counted in the inner or outer segment areas per two retinal sections from one mouse. Fractional numbers were rounded up to next whole integer
- cPLX5622 treatment was initiated at 90dpi and the last PLX5622-treated animal was euthanized at 134dpi