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Table 1 The effect of PLX5622 treatment on the types of cells infiltrating the retinal inner and outer segments during scrapie disease

From: Microglia are not required for prion-induced retinal photoreceptor degeneration

  Time (dpi)
82 104 118 129/131 134 144 153 159/163
No Drug n 2 2 2 2 0 2 2a 2a
IBA1 1,1b 5,14 15,14 26,22 na 23,27 26,12 6,10
GFP 1,0 4,15 9,18 18,22 na 25,30 19,10 6,8
RFP 0,0 0 0,2 1,0 na 1,3 3,2 1,1
PLX5622c n 0 2 2 5 1a 0 0 0
IBA1 na 0,0 0,2 1,2,2,4,4 7    
GFP na 1,0 1,2 0,2,2,4,2 8    
RFP na 0 0 1,1,0,1,0 3    
  1. dpi Days post inoculation, n Number of animals tested, IBA1 Ionized calcium binding adaptor molecule 1 (microglia, monocyte-macrophage marker), GFP Green fluorescent protein (microglial marker), RFP Red fluorescent protein (monocyte-macrophage marker), na not available
  2. aeuthanized for severe clinical disease
  3. beach number represents the mean number of IHC marker-positive, nucleated cells counted in the inner or outer segment areas per two retinal sections from one mouse. Fractional numbers were rounded up to next whole integer
  4. cPLX5622 treatment was initiated at 90dpi and the last PLX5622-treated animal was euthanized at 134dpi