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Fig. 9 | Acta Neuropathologica Communications

Fig. 9

From: Targeting the β2-integrin LFA-1, reduces adverse neuroimmune actions in neuropathic susceptibility caused by prenatal alcohol exposure

Fig. 9

I.t. BIRT-377 alters mRNA expression of specific chemokines only in PAE neuropathic rats. Ipsilateral SCN and DRG are collected from rats at Day 4 post-injection (Day 14 after minor CCI) for qRT-PCR analysis (rats from data shown in Fig. 7). Messenger RNA expression from ipsilateral (a) In SCN, CCL2, CXCL1, CXCL10 are significantly increased following minor CCI in PAE rats compared to Sac rats. CXCL1 is further increased in PAE rats vs. Sac rats given BIRT377. (b) In DRG, CCL2 is increased in Sac and PAE rats with minor injury while treatment with BIRT377 results in CXCL1 and CX3CL1 increases in PAE rats with minor injury

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Acta Neuropathologica Communications

ISSN: 2051-5960

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