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Fig. 8 | Acta Neuropathologica Communications

Fig. 8

From: Targeting the β2-integrin LFA-1, reduces adverse neuroimmune actions in neuropathic susceptibility caused by prenatal alcohol exposure

Fig. 8

PAE alters cytokine expression in the ipsilateral sciatic nerve and spinal cord. Ipsilateral sciatic nerve and spinal cord are collected at Day 4 post-injection (Day 14 after minor CCI) (rats from data shown in Fig. 7) and examined by multiplex protein analysis for levels of IL-10, IL-1β, TNFα, and CXCL1 (sciatic nerve only). Levels of protein are expressed as picograms of target protein per 100 μg of total protein. Data for ipsilateral (a) sciatic nerve and (b) lumbar spinal cord are represented. a IL-10 significantly increased in PAE rats with minor CCI given vehicle injection compared to Sac CCI vehicle injected rats. Additionally, compared to Sac/minor CCI vehicle injected rats and PAE sham vehicle rats, PAE minor CCI rats with vehicle injection displayed elevated levels of IL-1β, TNFα, and CXCL1. b IL-10 expression did not change significantly throughout any groups in the ipsilateral lumbar spinal cord. PAE minor CCI vehicle injected rats had significant increases in IL-1β expression compared to PAE sham vehicle rats. Additionally, no significant differences are seen in IL-1β between Sac minor CCI vehicle rats and PAE minor CCI vehicle rats. Significant differences in TNFα are seen between Sac minor CCI vehicle rats and PAE minor CCI rats. “1-sut CCI” = “minor CCI”. N = 4–6 rats per group. Asterisks indicate p < 0.05

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