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Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: Targeting the β2-integrin LFA-1, reduces adverse neuroimmune actions in neuropathic susceptibility caused by prenatal alcohol exposure

Fig. 7

BIRT-377 reverses PAE induced allodynia following i.t. injection. a-b At baseline (BL), rats displayed no differences in hindpaw sensitivity. Additionally, sham groups maintain normal sensitivity throughout the time-course demonstrating that repeated von Frey behavioral testing has no significant effects on touch stimuli. Additionally, PAE, but not Sac rats, develop robust unilateral allodynia as measured on Day 3 and 10. Following injection of BIRT-377, PAE rats return to normal sensitivity through Day 4 post-injection at which time, the experiment was terminated for tissue collection. “1-sut CCI” = “minor CCI”. Arrow indicates when i.t. injection was given. N = 4–6 rats per group. Asterisks indicate p < 0.05

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Acta Neuropathologica Communications

ISSN: 2051-5960

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