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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Targeting the β2-integrin LFA-1, reduces adverse neuroimmune actions in neuropathic susceptibility caused by prenatal alcohol exposure

Fig. 4

Increased basal levels of LFA-1 expression is present in PAE rats. Quantification of LFA-1 (Cd11a) immunoreactivity expression from behaviorally verified rats (Day 32 after minor CCI) (Fig. 1) reveal elevated expression of Cd11a observed in PAE- sham rats given vehicle compared to Sac-sham given vehicle. BIRT-377 injection resulted in significant decreases of Cd11a in PAE minor CCI rats. Additionally, no significant differences are observed between PAE rats given vehicle with sham or minor CCI. “1-sut CCI” = “minor CCI”. N = 5–8 rats per group. Asterisks indicate p < 0.05

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Acta Neuropathologica Communications

ISSN: 2051-5960

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