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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Targeting the β2-integrin LFA-1, reduces adverse neuroimmune actions in neuropathic susceptibility caused by prenatal alcohol exposure

Fig. 1

Enduring allodynia from minor injury in PAE rats is controlled by i.t. BIRT-377. Ipsilateral and contralateral hindpaw response thresholds from minor sciatic nerve injury (CCI) in adult PAE and Sac control rats. a-b At baseline (BL), rats displayed no differences in hindpaw sensitivity. a-b Following minor CCI, Sac control rats do not develop increased sensitivity whereas PAE rats develop enduring unilateral allodynia up to Day 28 post-surgery. c-d No changes in contralateral hindpaw sensitivity is observed following sham or CCI in Sac or PAE rats. a-b At Day 28, all animals received either vehicle or BIRT-377. a-b Following injection of BIRT-377, Sac rats maintain normal sensitivity. In contrast, allodynic rats with PAE return to normal sensitivity compared to vehicle injected rats. Sensitivity in the contralateral paw remained normal in all rat groups. N = 5–8 rats per group. Arrow indicates time of i.t. injection

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Acta Neuropathologica Communications

ISSN: 2051-5960

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