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Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: Downregulation of miR-204 expression defines a highly aggressive subset of Group 3/Group 4 medulloblastomas

Fig. 7

Effect of miR-204 expression on lysosomal enzymes and autophagy in medulloblastoma cells. a. Western blot analysis showing reduction in the levels of Cathepsin B (CTSB), Cathepsin D (CTSD) and increase in the levels of p62/SQSTM1 in the P1, P2 polyclonal populations of D283, D341 and HD-MB03 cells upon miR-204 expression. b. LC3BI, LC3BII levels in the miR-204 expressing polyclonal populations of D283, D341 and HD-MB03 cells as compared to the doxycycline treated vector control (VC) cells before and after treatment with Chloroquine for 1 h. The numbers below the western blots indicate the fold change in the indicated protein level or LC3BI / LC3B II ratio upon miR-204 expression using GAPDH as a house-keeping control

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