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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Downregulation of miR-204 expression defines a highly aggressive subset of Group 3/Group 4 medulloblastomas

Fig. 4

Effect of miR-204 expression on tumorigenicity of the medulloblastoma cells studied by monitoring orthotopic xenograft development. NOD/SCID mice were orthotopically injected with doxycycline treated vector control and P1 population expressing miR-204 of D283, D341 and HD-MB03 cells. a. Bioluminescence images of the injected mice on the indicated day post-injection of the indicated cell line. b. Y-axis denotes the fold increase in the average radiance of the tumor luminescence on day 28 or day 20 as compared to day 2 post-injection of the indicated cell population. c. Kaplan Meier Survival analysis of the injected mice. Significance in the difference in the survival upon miR-204 expression was determined by the Log Rank test. HR: Hazard Ratio; **, *** indicate p ≤ 0.001 and p ≤ .0001 respectively

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