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Table 3 Cell markers expressed by nervous tissue and inflammatory infiltrates in NMDAR-E-associated and control teratomas

From: Immunopathological characterization of ovarian teratomas associated with anti-N-methyl-D-aspartate receptor encephalitis

 

NMDAR-E teratomas (n = 27)

Control teratomas (n = 40)

p-value

Neuronal markers expression by neural elements when present, n (%)a

10/17 (58)

9/13 (69)

0.70

 ChromoA+

10/17 (59)

6/12 (50)

0.71

 NF+

7/17 (41)

7/13 (54)

0.71

GluN1 expression by neural element when present, n (%)a

18/22 (82)

11/14 (79)

1

 Neuronal

12/22 (55)

9/14 (64)

0.73

 Glial

16/22 (73)

4/14 (29)

0.015

Inflammatory infiltrates in contact to neural element when present, n (%)a

26/26 (100)

2/15 (13)

5. 10− 9***

 B-cells (CD20+)

19/23 (83)

 T-cells (CD3+)

22/23 (96)

 Mature dendritic cells (DC-Lamp+)

11/24 (46)

  1. aPercentages are calculated on the number of assessable cases. NF: neurofilament. ChromoA: chromogranin A
  2. ***: significant after Bonferroni correction for multiple comparisons, p<0.001