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Table 3 Cell markers expressed by nervous tissue and inflammatory infiltrates in NMDAR-E-associated and control teratomas

From: Immunopathological characterization of ovarian teratomas associated with anti-N-methyl-D-aspartate receptor encephalitis

  NMDAR-E teratomas (n = 27) Control teratomas (n = 40) p-value
Neuronal markers expression by neural elements when present, n (%)a 10/17 (58) 9/13 (69) 0.70
 ChromoA+ 10/17 (59) 6/12 (50) 0.71
 NF+ 7/17 (41) 7/13 (54) 0.71
GluN1 expression by neural element when present, n (%)a 18/22 (82) 11/14 (79) 1
 Neuronal 12/22 (55) 9/14 (64) 0.73
 Glial 16/22 (73) 4/14 (29) 0.015
Inflammatory infiltrates in contact to neural element when present, n (%)a 26/26 (100) 2/15 (13) 5. 10− 9***
 B-cells (CD20+) 19/23 (83)
 T-cells (CD3+) 22/23 (96)
 Mature dendritic cells (DC-Lamp+) 11/24 (46)
  1. aPercentages are calculated on the number of assessable cases. NF: neurofilament. ChromoA: chromogranin A
  2. ***: significant after Bonferroni correction for multiple comparisons, p<0.001