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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Immunopathological characterization of ovarian teratomas associated with anti-N-methyl-D-aspartate receptor encephalitis

Fig. 6

IgG and IgA deposits and producing cells in NMDAR-E associated teratomas. a Representative GFAP/IgG/IgA immunofluorescence (IF) staining of a NMDAR-E associated teratoma showing IgG (in red) and IgA (in white) deposits along a GFAP+ strip of neuroglial tissue (in green). Hoechst was used to visualize nuclei (blue) and pictures on the right correspond to individual channels. b Representative GFAP/IgG/IgA IF staining of a control teratoma without IgG nor IgA deposits in contact with GFAP+ neuroglial tissue. c GFAP/IgG/IgA IF staining of a NMDAR-E associated teratoma focused on GFAP+ neuroglial islands surrounded by immune cells and diffuse IgA deposits (white) and some isolated IgG+ cells (red). Hoechst was used to visualize nuclei (blue) and pictures on the right correspond to individual channels. d GFAP/IgG/IgA IF staining of a NMDAR-E teratoma showing individualized IgA+ cells (white) and IgG+ (red) in contact with GFAP+ neural elements (green) in a NMDAR-E associated teratoma. Scale bars: 50 μm

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