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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Immunopathological characterization of ovarian teratomas associated with anti-N-methyl-D-aspartate receptor encephalitis

Fig. 2

GluN1 expression by neuronal and glial cells in NMDAR-E associated and control ovarian teratomas. a Representative neuronal GluN1 immunostaining of ovarian teratomas associated with NMDAR-E. Neuronal expression of NMDAR subunit is detected in large ganglion cells (see cytoplasmic and weak nuclear staining on magnification). b Representative neuronal GluN1 immunostaining in the nervous tissue of a sporadic ovarian teratoma. Note the cerebellar-like organization with Purkinje-like cells expressing GluN1 (on magnification). c Representative glial GluN1 immunostaining of ovarian teratomas associated with NMDAR-E. GluN1 expression by astrocytic cells is cytoplasmic but also sometimes nuclear (on magnification). d Representative GluN1 immunostaining of sporadic mature ovarian teratomas with a nervous component. NMDAR subunit was expressed by neuropil, cell bodies of ganglion cells (arrows) and glial cells (on magnification). e-g Representative co-immunofluorescence stainings for GFAP (green) and GluN1 (red) in the central nervous tissue of NMDAR-E teratomas. h-j Representative co-immunofluorescence stainings for GFAP (green) and GluN1 (red) in the central nervous tissue of control teratomas. Scale bar: 50 μm

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