Fig. 1

Central nervous tissue in NMDAR-E-associated and control ovarian teratomas. (a-b) Representative hematoxylin-phloxine-saffron (HPS) gross structure of NMDAR-E mature ovarian teratomas. In case (a), a strip of central nervous tissue (outlined, black-dotted lines) lined the inner wall of a cystic cavity. In case (b), the central nervous tissue (outlined, black-dotted lines) formed a solid mass between connective and adipose tissues

(c-d) Representative HPS structure of immature ovarian teratomas associated with NMDAR-E. In (c), note the strip of central nervous tissue (outlined, black dotted lines) and the immature foci (arrowheads) with increased cellular density and neuroepithelial tubules. In case (d), the immature nervous contingent formed a solid mass lined with ependymal wall; note the choroid plexuses (arrowhead). e-f Representative HPS structure of control mature teratomas. The case (e) contained a strip of mature nervous tissue lining the wall of a cystic cavity (outlined, black dotted line). In the case (f), the solid mature nervous tissue was surrounded by connective and adipose tissue. Scale bar: 100 μm