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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Tau exhibits unique seeding properties in globular glial tauopathy

Fig. 2

Tau is the main contributor of tau seeding competency of GGT brain lysates. a A schematic diagram depicting the process of immunodepletion of tau from GGT brain lysates. b Successful removal of tau from the sample confirmed by Western blot using a human tau-specific antibody E1 (19–33 amino acid). c Representative confocal images showing formation of much fewer seeding-induced puncta in the tau biosensor cell line upon incubation with tau-immunodepleted GGT brain lysates (scale bar = 100 μm). d A significant decrease in tau seeding activity following immunodepletion of tau from GGT brain lysates, as quantified by the FRET flow cytometry assay. Data are presented as mean ± SD (**p < 0.01)

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