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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Tau exhibits unique seeding properties in globular glial tauopathy

Fig. 1

GGT brain lysates contain significantly higher tau seeding potency compared to other tauopathies. a Incubation of the tau biosensor cell line with brain lysates of sporadic or mutant (p.K317 N) GGT cases, resulted in induction of numerous GFP-positive puncta that are indicative of robust tau seeding. Representative confocal microscopy images are shown (scale bar = 100 μm). b Significant tau seeding activity of GGT brain lysates was measured by the FRET flow cytometry assay. FRET density was normalized to the amount of total tau present in the sample. Data are presented as mean ± SD (*p < 0.05 compared to control). c Analysis of p-tau burden from corresponding GGT and AD brain sections stained with CP13 p-tau antibody (pS202) demonstrated that GGT cases with similar p-tau burden to AD cases still induced robust FRET signals (R = 1, p = 0.0167 [GGT]; R = 0.8, p = ns [AD])

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