Table 1 Summary of patient demographics and Braak staging of AD-tau
|
CBD N = 49 |
PSP N = 109 |
PiD N = 22 | |
|---|---|---|---|
| Sex | M = 19 | M = 69 | M = 13 |
| F = 30 | F = 40 | F = 9 | |
| Age at death (years) | 67.5 (9.5) | 76 (71, 81)a | 67 (61, 74) |
| Age at onset (years) | 61.6 (9.3) | 67 (62,74)a | 57.8 (11.1) |
| Disease duration (years) | 6.0 (2.5) | 7 (4, 10)b | 9.0 (4.0) |
| PMI (hours) | 11 (5, 17) | 12 (6, 19) | 12.5 (7, 20) |
| Brain weight (g) | 1139 (139) | 1213 (1121, 1304)a | 1026 (161) |
| Clinical phenotype | CBS = 18 | PSP-RS = 61 | CBS = 2 |
| PSP = 12 | PSP-SL = 6 | PPA = 1 | |
| PPA = 9 | PSP-CBS = 8 | bvFTD-FTLD = 8 | |
| bvFTD-FTLD = 3 | PSP-F = 14 | FTD-NOS = 10 | |
| FTD- NOS = 4 | PSP-P = 8 | DLB = 1 | |
| AD = 1 | PSP-PGF = 1 | ||
| DLB = 1 | Other cognitive = 8 | ||
| Undetermined = 1 | Other motor = 3 | ||
| APOE haplotype | E2/E2 = 0 | E2/E2 = 2 | E2/E2 = 1 |
| E2/E3 = 8 | E2/E3 = 16 | E2/E3 = 1 | |
| E2/E4 = 0 | E2/E4 = 5 | E2/E4 = 0 | |
| E3/E3 = 33 | E3/E3 = 63 | E3/E3 = 16 | |
| E3/E4 = 7 | E3/E4 = 12 | E3/E4 = 3 | |
| E4/E4 = 1 | E4/E4 = 3 | E4/E4 = 0 | |
| N/A = 0 | N/A = 8 | N/A = 1 | |
| CERAD | 0 = 31 | 0 = 53 | 0 = 17 |
| 1 = 9 | 1 = 15 | 1 = 1 | |
| 2 = 3 | 2 = 14 | 2 = 1 | |
| 3 = 2 | 3 = 17 | 3 = 2 | |
| N/A = 4 | N/A = 10 | N/A = 1 | |
| Thal phase | 0 = 27 | 0 = 37 | 0 = 14 |
| 1 = 16 | 1 = 32 | 1 = 3 | |
| 2 = 3 | 2 = 21 | 2 = 4 | |
| 3 = 3 | 3 = 16 | 3 = 1 | |
| N/A = 0 | N/A = 3 | N/A = 0 | |
| Braak stage | B0 = 24 | B0 = 28 | B0 = 13 |
| B1 = 21 | B1 = 50 | B1 = 7 | |
| B2 = 4 | B2 = 25 | B2 = 1 | |
| B3 = 0 | B3 = 6 | B3 = 1 | |
| AD Neuropathological change | Not = 27 | Not = 38 | Not = 14 |
| Low = 19 | Low = 50 | Low = 7 | |
| Intermediate = 3 | Intermediate = 15 | Intermediate = 0 | |
| High = 0 | High = 4 | High = 1 |