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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Detection of Alzheimer’s disease (AD) specific tau pathology with conformation-selective anti-tau monoclonal antibody in co-morbid frontotemporal lobar degeneration-tau (FTLD-tau)

Fig. 4

Braak staging of FTLD-tau cohort with GT-38. AD-tau NFT burden was assessed in the hippocampus, pons/locus coeruleus, and visual cortex of 180 FTLD-tau cases and staged Braak 0–3. a The relative distribution of Braak stages across the entire cohort. b Age at death for each Braak stage (B0 n = 65, B1 n = 78, B2 n = 30, B3 n = 7) *** p < 0.001; * p < 0.05; n.s. = not significant; two-tailed t-test. c PSP cases (B0 = 28, B1 = 50, B2/B3 = 31) had significantly higher frequency of AD-tau (χ2 (4, n = 180) = 17.95; p = 0.0013) compared to CBD (B0 = 24, B1 = 21, B2/B3 = 4) and PiD (B0 = 13, B1 = 7, B2/B3 = 2)

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