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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Detection of Alzheimer’s disease (AD) specific tau pathology with conformation-selective anti-tau monoclonal antibody in co-morbid frontotemporal lobar degeneration-tau (FTLD-tau)

Fig. 2

GT-38 detects pathological tau aggregates containing 3R and 4R tau isoforms. Co-immunofluorescent staining of GT-38 with 3R- or 4R-tau specific antibodies in a AD midfrontal cortex, b CBD, PSP, and PiD hippocampus in regions with co-occurring AD-tau pathology, demonstrating complete colocalization with 4R tau in the context of PiD and complete colocalization with 3R tau pathology in the context of CBD and PSP, c GT-38 negative regions in CBD, PSP, and PiD hippocampus without concomitant AD-tau pathology, but with tau pathology comprised of only 3R- or 4R-tau respectively

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Acta Neuropathologica Communications

ISSN: 2051-5960

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