Fig. 1

GT-38 selectively detects AD-tau pathology in the context of co-occurring FTLD-tau. IHC staining of hippocampus CA1, dentate gyrus, and pons with GT-38 or phospho-tau antibody PHF1 demonstrates that GT-38 detects tau NFTs in CA1 region but not neuronal inclusions in the molecular layer of the dentate gyrus present in FTLD-tau. GT-38 does not detect neuronal or astrocytic tau pathology in pons of FTLD-tau cases verifying selectivity of GT-38 for AD-tau pathology