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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Detection of Alzheimer’s disease (AD) specific tau pathology with conformation-selective anti-tau monoclonal antibody in co-morbid frontotemporal lobar degeneration-tau (FTLD-tau)

Fig. 1

GT-38 selectively detects AD-tau pathology in the context of co-occurring FTLD-tau. IHC staining of hippocampus CA1, dentate gyrus, and pons with GT-38 or phospho-tau antibody PHF1 demonstrates that GT-38 detects tau NFTs in CA1 region but not neuronal inclusions in the molecular layer of the dentate gyrus present in FTLD-tau. GT-38 does not detect neuronal or astrocytic tau pathology in pons of FTLD-tau cases verifying selectivity of GT-38 for AD-tau pathology

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Acta Neuropathologica Communications

ISSN: 2051-5960

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