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Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: Autoradiography validation of novel tau PET tracer [F-18]-MK-6240 on human postmortem brain tissue

Fig. 7

Photomicrographs showing combined [F-18]-MK-6240 high-resolution nuclear emulsion autoradiography followed by immunostaining with appropriate antibodies of brain slices containing frontal and temporal cortices from AD (#10, #16) (a-c), CAA (#17) (d) CTE (#33) (e), CBD (#23) (f), PSP (#26) (g), PiD (#20) (h), LBD (#34) (i) and FTLD TDP-43 (#39) (j). Accumulation of silver grains from the nuclear emulsion colocalized with PHF-1 stained tangles and PHF-tau containing dystrophic neurites around plaques in AD. No detectable accumulations of silver grains were observed in association with Aβ plaques themselves or amyloid-containing vessels in CAA, tau aggregates in CTE, coiled bodies and globose tangles in CBD, astrocytic plaques in PSP, Pick bodies in PiD, Lewy bodies in LBD or TDP-43 inclusions in FTLD TDP-43. Abbreviations: AD = Alzheimer’s disease; CAA = cerebral amyloid angiopathy; CTE = chronic traumatic encephalopathy; CBD = corticobasal degeneration PSP = progressive supranuclear palsy; PiD = Pick’s disease; LBD = Lewy body disease; FTLD TDP-43 = frontotemporal lobar degeneration with TDP-43 inclusions. Scale bar = 50 μm

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