Fig. 5

Phosphor screen autoradiography experiments in slices containing entorhinal and temporal cortices from AD cases using competing concentrations of 1 μM clorgyline (a selective MAO-A inhibitor) and deprenyl (MAO-B inhibitor). [F-18]-MK-6240 and [F-18]-AV-1451 binding signals are only weakly displaced (by about 20%) with 1 μM deprenyl (a selective MAO-B inhibitor). When a competing concentration of 1 μM clorgyline (a selective MAO-A inhibitor) was added to the blocking solution, neither [F-18]-MK-6240 nor [F-18]-AV-1451 autoradiographic signal displacement could be detected. Scale bar = 1 cm