Fig. 3
From: Autoradiography validation of novel tau PET tracer [F-18]-MK-6240 on human postmortem brain tissue
[F-18]-MK-6240 phosphor screen and high-resolution autoradiography images of slices containing substantia nigra in a control case (#2) (a), retinal pigment epithelium (b) in an AD case (#11), metastatic melanoma (#18) (c), parenchymal hemorrhagic lesions (#43) (d) and extracutaneous meningeal melanocytes in the cerebellum of an AD case (#8) (e). [F-18]-MK-6240 phosphor screen autoradiography images are displayed in (a-e), left and middle panels. [F-18]-MK-6240 high resolution autoradiography images are displayed in (a-e), right panel. Strong [F-18]-MK-6240 binding was observed in neuromelanin-containing neurons of the substantia nigra (a), melanin containing granules in the retinal pigment epithelium (b), malignant melanocytes from a metastatic melanoma (c), and extracutaneous meningeal melanocytes (e). [F-18]-MK-6240 binding was noticed in association with intraparenchymal hemorrhagic lesions (d). Scale bars = 1 cm (a-e left and middle panels: phosphor screen autoradiography) and 50 μm (a-e right panels; high resolution nuclear emulsion autoradiography)