Fig. 2

[F-18]-MK-6240 phosphor screen images of brain slices from a CAA carrier of the D23N Iowa APP mutation (#17) (a), FTLD TDP-43 (#40, #41) (b), LBD (#36) (c), and MSA (#37) (d) cases. No [F-18]-MK-6240 binding was detected in slices containing CAA lesions (a), TDP-43 inclusions (b), Lewy bodies (c) and glial α-synuclein inclusions (d). Strong [F-18]-MK-6240 signal was observed in the region corresponding to the substantia nigra (off-target) in all cases studied regardless of their pathological diagnosis (c). Abbreviations: APP = amyloid precursor protein; CAA = cerebral amyloid angiopathy; TDP-43 = TAR DNA binding protein 43; DLB = dementia with Lewy bodies; MSA = multiple system atrophy. Scale bar = 1 cm