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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Postnatal development and maturation of layer 1 in the lateral prefrontal cortex and its disruption in autism

Fig. 3

Myelinated axons in LPFC layer 1 analyzed at the electron microscope level in young children [cases 451 (a), 4021 (b)], older children [cases M3835 M (c), AN 03321 (d)], and adults [cases 5353 (e), 5173 (f), 4981(g), 6232 (h)] illustrate described trends. In younger children, who overall had fewer myelinated axons, there is still visible reduction in density of myelinated axons in individuals with autism (b). In older children there was a clear increase in the density of myelinated axons in autistic children (d), representing the variability inherent in autism, and multiple branching axons can be seen within the field. In adults, there was a decrease in proportion of small axons in individuals with autism with no visible change in overall axon density (p = 0.390) (f, h). Scale bar in (h) applies to all panels

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