Fig. 8

ADan oligomers do not reduce LTP in slices of Tau^−/− mice. a ADan oligomers reduce LTP in slices of WT mice. Hippocampal Schaffer collateral-CA1 LTP in WT mice in control (circles) or after incubation with ADan oligomers (squares). Representative traces are the average baseline fEPSP (1–10 min) and average fEPSP of the final 10 min of recording (40–50 min) for each condition. b Hippocampal Schaffer collateral-CA1 LTP in Tau^−/− mice in control (circles) or after incubation with ADan oligomers (squares). ADan oligomers do not reduce LTP in slices of Tau^−/− mice. The inset shows superimposed example traces before and 40 min after high-frequency stimulation for each condition. c Data show average of normalized fEPSP slope for final 10 min of recording (40–50 min) relative to 10 min baseline average. For WT; p = 0.0007, t₁₂ = 4.537, Unpaired Student’s t test; n = 8 slices Ctrl from 4 mice, n = 6 slices ADan oligomer (400 nM) from 4 mice. For Tau^−/−; p = 0.9440, t₁₃ = 0.0716, Unpaired Student’s t test; n = 7 slices Ctrl from 4 mice, n = 8 slices ADan oligomer (400 nM) from 4 mice